HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Azetidin-1-YL)piperidine → 2-(4-Azetidin-1-ylpiperidin-ylmethyl)-5-chloro-7-morpholin-4-ylthiazolo[4,5-d]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Azetidin-1-YL)piperidine | HCID 23153109 | — |
| Reactant | 5-(5-Chloro-7-morpholin-4-yl-thiazolo[4,5-d]pyrimidin-2-ylmethyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester | HCID 58234937 | — |
| Product | 2-(4-Azetidin-1-ylpiperidin-ylmethyl)-5-chloro-7-morpholin-4-ylthiazolo[4,5-d]pyrimidine | HCID 58234932 | — |
Reaction Steps
Prepared according to the method used in the preparation of 5-(5-chloro-7-morpholin-4-ylthiazolo[4,5-d]pyrimidin-2-ylmethyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester using 4-azetidin-1-yl piperidine in place of hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester. The title compound was obtained as a yellow solid (97 mg, 33%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07893060B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-393f4a0d6ed6464cac66ac40ab9bdc9c |
| Source note | uspto-grants-2011_02 |