HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Tert-butyl Piperazine-1-carboxylate Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Tert-butyl Piperazine-1-carboxylate Hydrochloride | HCID 2755973 | — |
Reaction Steps
To a solution of tert-butyl-1-piperazinecarboxylate (15.0 g) in dichloromethane (150 mL) and methanol (150 mL) at 0° C. was added hydrogen chloride (40 mL; 2M solution in diethyl ether). The mixture was stirred at room temperature for 1.5 hours and reduced in vacuo to yield tert-butyl-1-piperazinecarboxylate hydrochloride (17.9 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07893060B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-3ceda88af95e4fa396dda40dfad40318 |
| Source note | uspto-grants-2011_02 |