tert-Butyl piperazine-1-carboxylate → HCID 58234950, compound

HRID 1365876Notes

Reaction equation

HRID 1365876 reaction equation
N1(C2[CH2:10][CH2:9][N:8]([CH2:11][C:12]3[S:13][C:14]4[N:15]=[C:16]([Cl:27])[N:17]=[C:18]([N:21]5[CH2:26][CH2:25][O:24][CH2:23][CH2:22]5)[C:19]=4[N:20]=3)[CH2:7][CH2:6]2)CCC1.[C:28]([O:32][C:33]([N:35]1CCNCC1)=[O:34])([CH3:31])([CH3:30])[CH3:29]>>[C:28]([O:32][C:33]([N:35]1[CH2:6][CH2:7][N:8]([CH2:11][C:12]2[S:13][C:14]3[N:15]=[C:16]([Cl:27])[N:17]=[C:18]([N:21]4[CH2:22][CH2:23][O:24][CH2:25][CH2:26]4)[C:19]=3[N:20]=2)[CH2:9][CH2:10]1)=[O:34])([CH3:31])([CH3:30])[CH3:29]

Participants

3

Reactant 2

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 582349332-(4-Azetidin-1-ylpiperidin-1-ylmethyl)-5-chloro-7-morpholin-4-ylthiazolo[5,4-d]pyrimidine

Product 1

HCID 58234950HCID 58234950, compound

Procedure

Prepared according to the method used in the preparation of 2-(4-azetidin-1-ylpiperidin-1-ylmethyl)-5-chloro-7-morpholin-4-ylthiazolo[5,4-d]pyrimidine using piperazine-1-carboxylic acid tert-butyl ester in place of 4-azetidin-1-ylpiperidine. The title compound was obtained as a white solid (129 mg, 81%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-dbe65797928240a2bc0ad62fb7af2279
Source dataset
uspto-grants-2011_02
Patent number
US07893060B2

Reaction notes

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