Sodium t-butoxide → HCID 23653612, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-(1-acetyl-3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-3-((2-amino-5-pyrimidinyl)ethynyl)-4-methyl-2(1H)-pyridinone (0.103 g, 0.25 mmol) and sodium tert-butoxide (0.072 g, 0.75 mmol) in tBuOH (4 mL) was heated under microwave radiation at 100° C. for 10 min. The reaction mixture was diluted with EtOAc and washed with saturated NH4Cl and brine. The solids formed were filtered and recombined with the organic fraction. After concentrating the organic fraction in vacuo, the residue was purified by silica gel chromatography using 0-10% MeOH in EtOAc to afford 3-((2-amino-5-pyrimidinyl)ethynyl)-1-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-4-methyl-2(1H)-pyridinone as a light yellow solid. Found M+H+=372.3.

Provenance & Evidence