HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → 3-[(1-Benzylpiperidin-4-yl)amino]pyrazine-2-carbohydrazide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | Methyl 3-[(1-benzylpiperidin-4-yl)amino]pyrazine-2-carboxylate | HCID 22293191 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-[(1-Benzylpiperidin-4-yl)amino]pyrazine-2-carbohydrazide | HCID 22293315 | — |
Reaction Steps
A mixture of methyl 3-[(1-benzylpiperidin-4-yl)amino]pyrazine-2-carboxylate (3.0 g, 9.2 mmol) and hydrazine hydrate (6 mL) in ethanol (100 mL) was refluxed with stirring for 2 h. The reaction was cooled and concentrated to give the title compound (3.0 g). MS 327 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07893052B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-0f72a7a7a47d40dc8343a2f39a2f7178 |
| Source note | uspto-grants-2011_02 |