HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1366206Generated: October 25, 2026
Stannous chloride dihydrate → 5-Morpholinopyridin-2-amine
https://huagongshe.com/reaction/1366206
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Stannous chloride dihydrate | HCID 61436 | — |
| Reactant | 4-(6-Nitropyridin-3-yl)morpholine | HCID 2927973 | — |
| Reactant | 4-{8-[4-(4-Pyridin-2-yl-[1,2,3]triazol-1-yl)-phenylamino]-imidazo[1,2-a]pyrazin-5-yl}-benzamide | HCID 17757332 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-Morpholinopyridin-2-amine | HCID 11367346 | 87% |
Reaction Steps
In the same way as described in for Compound 154, step 2 using 4-(6-nitro-pyridin-3-yl)-morpholine (2.39 g, 11.43 mmol), tin(II) chloride dihydrate (12.9 g, 57.17 mmol) in MeOH (40 mL) and conc. HCl (12.4 mL). The reaction mixture is concentrated in vacuo cooled to 0° C. and dissolved in water. The aqueous solution is basified using conc. NaOH and extracted with ethyl acetate (3×). The organic layers are combined, dried over MgSO4, filtered and concentrated to afford the title compound (1.77 g, 87%) which is used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07893058B2 |
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| Source dataset | uspto-grants-2011_02 |
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| ORD ID | ord-3d3ad81974fa4d4390cba3d02e5ea22e |
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| Source note | uspto-grants-2011_02 |
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