2-Aminothiazole → HCID 66966772, compound

Participants

Reaction Conditions

Reaction Steps

22.9 g (119.9 mmol) 5-bromo-thiophene-2-carbaldehyde and 11.0 g (131.9 mmol) tert.-butyl-isonitrile were added to a solution of 12.0 g (119.9 mmol) 2-amino-thiazole in chloroform (60 ml). A 1 molar perchloric acid (2.3 ml) was added to the reaction solution and heated to 50° C. while being stirred for 5 d. After cooling to RT, dilution with DCM was performed and a 1 molar aq. Na2CO3 sol. added. After 10 min of stirring at RT, the phases were separated. The organic phase was dried over Na2SO4, filtered and concentrated in a vacuum. 6.6 g (18.5 mmol, 15%) 6-(5-bromothiophene-2-yl)-N-tert-butylimidazo[2,1-b]thiazole-5-amine ([MH+] 356.0) was obtained by crystallisation of the residue from AE.

Provenance & Evidence