Benzyl 4-(cyclopropylcarbonyl)piperazine-1-carboxylate → 1-(Cyclopropylcarbonyl)piperazine

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Reaction Steps

In 100 mL of ethanol was dissolved benzyl 4-(cyclopropylcarbonyl)piperazine-1-carboxylate (3.00 g, 10.4 mmol), and 1.5 g of 10% palladium-carbon was added thereto, followed by stirring at room temperature under hydrogen atmosphere overnight. The palladium-carbon was removed by filtration, and the filtrate was evaporated to give the title compound (1.50 g, 97.3%) as a colorless oil.

Provenance & Evidence