HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → {[((2R)1,4-dioxan-2-ylmethyl)(methyl)amino]sulfonyl}ammonium trifluoroacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Tert-butyl {[(1,4-dioxan-2-ylmethyl)(methyl)amino]sulfonyl}carbamate | HCID 76006351 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | {[((2R)1,4-dioxan-2-ylmethyl)(methyl)amino]sulfonyl}ammonium trifluoroacetate | HCID 66972081 | — |
Reaction Steps
tert-butyl {[(1,4-dioxan-2-ylmethyl)(methyl)amino]sulfonyl}carbamate (1.25 g, 4.03 mmol) was dissolved in 10 mL dichloromethane and 20 mL trifluoroacetic acid and stirred at ambient temperature. After 2 hours, the solution was concentrated and azeotroped twice with heptane to afford the title compound. LRMS (APCI) calc'd for (C6H15N2O4S) [M+H]+, 211.1; found, 211.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07893081B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-c60ea02153ae4a988ecf536abbc79e27 |
| Source note | uspto-grants-2011_02 |