1,2-Dichloroethane → HCID 14804457, compound

Participants

Reaction Steps

Pyrrolidine (1668 uL, 2 mmol), N-CBZ-D-alanine (446 mg, 2 mmol), and HOAt (272 mg, 2 mmol) were dissolved in 6 mL of dichloromethane. NMM (0.44 mL, 4 mmol) was added, followed by EDC (382 mg, 2 mmol). After stirring overnight at room temperature, the reaction mixture was diluted with EtOAc, washed with water, saturated aqueous NaHCO3 solution, and saturated aqueous NH4Cl solution, then dried (Na2SO4) and evaporated to yield phenylmethyl [(1R)-1-methyl-2-oxo-2-(1-pyrrolidinyl)ethyl]carbamate as a white solid (496 mg, 90%). LCMS: (M+H)+: 277.2.

Provenance & Evidence