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HRID1366434

反应详情

EQUATION

反应方程式

HRID 1366434 的结构方程式

REACTANTS

反应物

1
反应SMILES：CCN1CCN(c2nc(OC)nc(NNC(=O)[C@H](CC3CCCC3)CN(C=O)OCc3ccccc3)c2F)CC1
HCID86636936

未命名化合物

PRODUCTS

产物

1
反应SMILES：CCN1CCN(c2nc(OC)nc(NNC(=O)[C@H](CC3CCCC3)CN(O)C=O)c2F)CC1
HCID58000761

未命名化合物

收率 98%

AUXILIARIES

试剂、催化剂与溶剂

1
反应SMILES：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

A solution of ((2R)-2-(cyclopentylmethyl)-3-{2-[6-(4-ethyl-1-piperazinyl)-5-fluoro-2-(methyloxy)-4-pyrimidinyl]hydrazino}-3-oxopropyl)[(phenylmethyl)oxy]formamide (0.145 g, 0.26 mmol), and Pd(C) (0.030 g) in MeOH (10 mL) was run under standard hydrogenation conditions as in General Procedure A, Part C, to provide ((2R)-2-(cyclopentylmethyl)-3-{2-[6-(4-ethyl-1-piperazinyl)-5-fluoro-2-(methyloxy)-4-pyrimidinyl]hydrazino}-3-oxopropyl)hydroxyformamide as a red solid (0.119 g, 98%). LCMS: (M+H)+=468.4.