HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → (2S)-2-amino-N,N-dimethylbutanamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | Dimethylamine, hydrochloride | HCID 10473 | — |
| Reactant | 2-Amino-1-(pyrrolidin-1-yl)ethan-1-one hydrochloride | HCID 21949208 | — |
| Product | (2S)-2-amino-N,N-dimethylbutanamide hydrochloride | HCID 57517874 | — |
Reaction Steps
(2S)-2-Amino-N,N-dimethylbutanamide, hydrochloride salt was prepared in a manner similar to 2-oxo-2-(1-pyrrolidinyl)ethanamine, hydrochloride salt (Example 69), utilizing N-CBZ-L-2-aminobutyric acid in place of N-CBZ-glycine, utilizing dimethylamine, hydrochloride salt in place of pyrrolidine, and using 3 equivalents of NMM in Part A. (M+H)+: 130.9.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07893056B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-183a9cbf258142d9ac9b5824b493aca4 |
| Source note | uspto-grants-2011_02 |