(2S)-2-{[6-{2-[(2R)-3-cyclopentyl-2-({formyl[(phenylmethyl)oxy]amino}methyl)propanoyl]hydrazino}-5-fluoro-2-(methyloxy)-4-pyrimidinyl]amino}-N,N-dimethylbutanamide → (2S)-2-{[6-[2-((2R)-3-cyclopentyl-2-{[formyl(hydroxy)amino]methyl}propanoyl)hydrazino]-5-fluoro-2-(methyloxy)-4-pyrimidinyl]amino}-N,N-dimethylbutanamide

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Reaction Steps

A solution of (2S)-2-{[6-{2-[(2R)-3-cyclopentyl-2-({formyl[(phenylmethyl)oxy]amino}methyl)propanoyl]hydrazino}-5-fluoro-2-(methyloxy)-4-pyrimidinyl]amino}-N,N-dimethylbutanamide (0.036 g, 0.063 mmol), and Pd(C) (0.008 g) in MeOH (10 mL) was run under standard hydrogenation conditions as in General Procedure A, Part C, to provide (2S)-2-{[6-[2-((2R)-3-cyclopentyl-2-{[formyl(hydroxy)amino]methyl}propanoyl)hydrazino]-5-fluoro-2-(methyloxy)-4-pyrimidinyl]amino}-N,N-dimethylbutanamide as an orange solid (0.019 g, 63%). LCMS: (M+H)+=484.4.

Provenance & Evidence