Hydrazine hydrate (1:1) → HCID 66936103, compound

Participants

Reaction Steps

To 4-chloro-6-[(3S)-3,4-dimethyl-1-piperazinyl]-5-fluoro-2-methylpyrimidine (0.254 g, 0.98 mmol) in DMSO (3 mL) was added hydrazine monohydrate (2 mL). The reaction was stirred at room temperature for 3 days. The volatiles were removed in vacuo, and the residue was purified by RP-HPLC to provide 4-[(3S)-3,4-dimethyl-1-piperazinyl]-5-fluoro-6-hydrazino-2-methylpyrimidine as a yellow solid (0.161 g, 64%). LCMS: (M+H)+=255.6.

Provenance & Evidence