[(2R)-2-(Cyclopentyl methyl)-3-(2-{5-fluoro-2-methyl-6-[methyl (4-pyridinylmethyl)amino]-4-pyrimidinyl}hydrazino)-3-oxopropyl](tetrahydro-2H-pyran-2-yloxy)formamide → HCID 58000649, compound

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[(2R)-2-(Cyclopentylmethyl)-3-(2-{5-fluoro-2-methyl-6-[methyl(4-pyridinylmethyl)amino]-4-pyrimidinyl}hydrazino)-3-oxopropyl](tetrahydro-2H-pyran-2-yloxy)formamide (0.0979 g, 0.1802 mmol) was dissolved in acetic acid (8 mL) and water (2 mL). The reaction was left to stir overnight. The volatiles were evaporated, and the resulting material was purified by RP-HPLC to provide [(2R)-2-(cyclopentylmethyl)-3-(2-{5-fluoro-2-methyl-6-[methyl(4-pyridinylmethyl)amino]-4-pyrimidinyl}hydrazino)-3-oxopropyl]hydroxyformamide as a beige solid (0.0273 g, 33%). LCMS: (M+H)+=460.7.

Provenance & Evidence