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HRID1366484

反应详情

EQUATION

反应方程式

HRID 1366484 的结构方程式

REACTANTS

反应物

1
结构：CC1(C)CN(c2nc(Cl)nc(NNC(=O)[C@H](CC3CCCC3)CN(C=O)OC3CCCCO3)c2F)C[C@H]1O
HCID86636956

未命名化合物

PRODUCTS

生成物

1
结构：CC1(C)CN(c2nc(Cl)nc(NNC(=O)[C@H](CC3CCCC3)CN(O)C=O)c2F)C[C@H]1O
HCID58000541

未命名化合物

收率 63%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(=O)O.O
溶剂HCID21899381

Acetic acid--water (1/1)

C2H6O3

PROCEDURE

实验过程

A solution of [(2R)-3-(2-{2-chloro-5-fluoro-6-[(4S)-4-hydroxy-3,3-dimethyl-1-pyrrolidinyl]-4-pyrimidinyl}hydrazino)-2-(cyclopentylmethyl)-3-oxopropyl](tetrahydro-2H-pyran-2-yloxy)formamide (0.1294 g, 0.232 mmol) in 4:1 HOAc-water (5 mL) was heated at 30° C. and stirred overnight. The solution was cooled to room temperature, concentrated in vacuo, and purified directly by Gilson RPLC to give [(2R)-3-(2-{2-chloro-5-fluoro-6-[(4S)-4-hydroxy-3,3-dimethyl-1-pyrrolidinyl]-4-pyrimidinyl}hydrazino)-2-(cyclopentylmethyl)-3-oxopropyl]hydroxyformamide (69.1 mg, 63% yield) as a yellow solid. LCMS: (M+H)+: 473.2.

WORKUP

后处理

  1. concentrationconcentrated in vacuo
  2. custompurified directly by Gilson RPLC