Hydrazine hydrate (1:1) → 6-{[(2-Amino-1,3-thiazol-4-yl)methyl]amino}-5-fluoro-4-hydrazino-2-methylpyrimidine

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Reaction Steps

N-[(2-Amino-1,3-thiazol-4-yl)methyl]-6-chloro-5-fluoro-2-methyl-4-pyrimidinamine (450 mg, 1.56 mmol) was dissolved in 5 ml of DMSO and 5 ml of hydrazine monohydrate was added. The mixture was stirred overnight and was purified by RP-HPLC to provide 6-{[(2-amino-1,3-thiazol-4-yl)methyl]amino}-5-fluoro-4-hydrazino-2-methylpyrimidine (125 mg, 28%). LCMS: (M+H)+: 284.1.

Provenance & Evidence