Hydrazine hydrate (1:1) → 1-(2-Chloro-5-fluoro-6-hydrazino-4-pyrimidinyl)-3-methyl-3-pyrrolidinol

Participants

Reaction Steps

1-(2,6-Dichloro-5-fluoro-4-pyrimidinyl)-3-methyl-3-pyrrolidinol (0.486 g, 1.83 mmol) and hydrazine monohydrate (0.53 mL, 10.96 mmol) in DMSO (5 mL) were heated at 50° C. until the reaction was deemed complete. Purification by RP-HPLC provided 1-(2-chloro-5-fluoro-6-hydrazino-4-pyrimidinyl)-3-methyl-3-pyrrolidinol as a brown solid (0.104 g, 21%). LCMS: (M+H)+=262.1.

Provenance & Evidence