Sodium Acetate → HCID 87210078, compound

Participants

Reaction Steps

To a solution of 2,2-dimethyl-1-(phenylcarbonyl)-3-pyrrolidinone (2.0602 g, 9.482 mmol) in MeOH (50 mL) was added sodium acetate (0.956 g, 11.38 mmol) and methoxyamine hydrochloride (0.950 g, 11.37 mmol). The mixture was stirred overnight and then concentrated in vacuo. The residue was dissolved in DCM (200 mL) and washed with sat. aq. NaHCO3 (50 mL), water (50 mL), and brine (50 mL). The organic phase was dried over anhydrous Na2SO4, filtered, and concentrated in vacuo to afford (3E)-2,2-dimethyl-1-(phenylcarbonyl)-3-pyrrolidinone O-methyloxime (1.9567 g, 84% yield) as a light yellow oil that solidified under high vacuum. LCMS: (M+H)+: 247.2.

Provenance & Evidence