Hydrochloric Acid → HCID 23090152, compound

Participants

Reaction Steps

To a solution of racemic N,N,2,2-tetramethyl-1-(phenylmethyl)-3-pyrrolidinamine (0.5637 g, 2.426 mmol) in MeOH (24 mL) was added 1 N aq. HCl (4.9 ml) and 10% Pd/C (50% water, 113 mg). The mixture was hydrogenated overnight, and then filtered through a 0.2 μM membrane. The resulting solution was concentrated in vacuo. The residue was diluted with 1 N aq. NaOH (20 mL) and extracted with DCM (2×100 mL). The combined organic phase was dried over anhydrous Na2SO4, filtered, and concentrated in vacuo to afford crude, racemic N,N,2,2-tetramethyl-3-pyrrolidinamine (0.2930 g, 85% yield) as a pale yellow oil. LCMS: (M+H)+: 143.1.

Provenance & Evidence