Hydrochloric Acid → HCID 131728711, compound

Participants

Reaction Steps

To a solution of racemic tris(1,1-dimethylethyl)2-{2-chloro-6-[3-(dimethylamino)-2,2-dimethyl-1-pyrrolidinyl]-5-fluoro-4-pyrimidinyl}-1,1,2-hydrazinetricarboxylate (0.4618 g, 0.766 mmol) in MeOH (5 mL) was added 4 N HCl in dioxane (5 mL). The solution was stirred for 3 days, and then concentrated in vacuo to afford racemic 1-(2-chloro-5-fluoro-6-hydrazino-4-pyrimidinyl)-N,N,2,2-tetramethyl-3-pyrrolidinamine pentahydrochloride (0.3673 g, 99% yield) as an orange oil that crystallized under vacuum. LCMS: (M+H)+: 303.1.

Provenance & Evidence