Diethyl Ether → HCID 86636984, compound

Participants

Reaction Steps

To a solution of tris(1,1-dimethylethyl)2-(2,6-dichloro-5-fluoro-4-pyrimidinyl)-1,1,2-hydrazinetricarboxylate (0.497 g, 1.0 mmol) in DMF (5 mL) at room temperature was added diisopropylethylamine (0.19 mL, 1.10 mmol) followed immediately by commercially available cyclobutylamine (0.085 mL, 1.0 mmol). The reaction was stirred for 4 days, then ether was added, and the mixture was washed with water and the aqueous layer was back extracted. The combined organics were dried (Na2SO4), concentrated in vacuo, and azeotroped once with MeOH to provide tris(1,1-dimethylethyl)2-[2-chloro-6-(cyclobutylamino)-5-fluoro-4-pyrimidinyl]-1,1,2-hydrazinetricarboxylate as a white solid.

Provenance & Evidence