Dichloromethane → HCID 131728712, compound

Participants

Reaction Steps

1,1-Dimethylethyl (2S)-4-methyl-2-(1-methylethyl)-1-piperazinecarboxylate (2.18 g crude, 8.76 assumed mmol) was dissolved in a mixture of MeOH (5 mL), CH2Cl2 (5 mL), and 4 N HCl in dioxane (8 mL). After stirring overnight at room temperature, another 8 mL of 4 N HCl in dioxane and 8 mL of MeOH were added, which dissolved the white precipitate that had formed and pushed the reaction to completion. Evaporation of the solvents in vacuo provided (3S)-1-methyl-3-(1-methylethyl)piperazine, dihydrochloride (1.97 g) as a white solid.

Provenance & Evidence