反应详情

Methyl 1-(methyl{[(phenylmethyl)oxy]carbonyl}amino)cyclopropanecarboxylate (assumed 6.8 g, 25.91 mmol, 100% theoretical yield) was dissolved in 30 mL of MeOH, degassed and placed under argon. 10% Pd/C (2.04 g) was added, and the contents were thoroughly degassed and placed under a hydrogen balloon overnight. The contents were then degassed, and the Pd/C was removed by filtration through Celite, washing with MeOH. The filtrate was concentrated in vacuo to provide pure methyl 1-(methylamino)cyclopropanecarboxylate (1.53 g, 45% over two step). LCMS: (M+H)+: 130.1.

1. customdegassed
2. addition10% Pd/C (2.04 g) was added
3. customthe contents were thoroughly degassed
4. customballoon overnight
5. customThe contents were then degassed
6. customthe Pd/C was removed by filtration through Celite
7. washwashing with MeOH
8. concentrationThe filtrate was concentrated in vacuo