Hydrochloric Acid → HCID 178514349, compound

Participants

Reaction Steps

To a solution of tris(1,1-dimethylethyl)2-[2-chloro-5-fluoro-6-(tetrahydro-2H-pyran-4-ylamino)-4-pyrimidinyl]-1,1,2-hydrazinetricarboxylate (0.602 g, 1.071 mmol) in MeOH (20 mL) was added 4M HCl in 1,4-dioxane (20 mL). After stirring at room temperature for 2 days, the solvent was evaporated and saturated NaHCO3 was added. The aqueous layer was extracted, and the organics were dried (Na2SO4) and concentrated in vacuo to provide 2-chloro-5-fluoro-6-(tetrahydro-2H-pyran-4-ylamino)-4(1H)-pyrimidinone hydrazone as a red solid (0.199 g). LCMS: (M+H)+=261.8.

Provenance & Evidence