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HRID1366590

反应详情

EQUATION

反应方程式

HRID 1366590 的结构方程式

REACTANTS

反应物

2
结构：CC(=O)O
HCID176

Acetic Acid

C2H4O2

结构：Cc1nc(NNC(=O)[C@H](CC2CCCC2)CN(C=O)OC2CCCCO2)c(F)c(N2CC(C)(N3CCCC3)C2)n1
HCID86636996

[(2R)-2-(cyclopentylmethyl)-3-(2-{5-fluoro-2-methyl-6-[3-methyl-3-(1-pyrrolidinyl)-1-azetidinyl]-4-pyrimidinyl}hydrazino)-3-oxopropyl](tetrahydro-2H-pyran-2-yloxy)formamide

C28H44FN7O4

PRODUCTS

生成物

1
结构：Cc1nc(NNC(=O)[C@H](CC2CCCC2)CN(O)C=O)c(F)c(N2CC(C)(N3CCCC3)C2)n1
HCID58000653

未命名化合物

收率 64.8%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O
溶剂HCID962

Water

H2O

PROCEDURE

实验过程

A solution of [(2R)-2-(cyclopentylmethyl)-3-(2-{5-fluoro-2-methyl-6-[3-methyl-3-(1-pyrrolidinyl)-1-azetidinyl]-4-pyrimidinyl}hydrazino)-3-oxopropyl](tetrahydro-2H-pyran-2-yloxy)formamide (118 mg) in 4:1 AcOH:water (20 mL) was stirred at room temperature for 3 days. The solvents were removed in vacuo, and the resulting crude product was purified by RP-HPLC to provide [(2R)-2-(cyclopentylmethyl)-3-(2-{5-fluoro-2-methyl-6-[3-methyl-3-(1-pyrrolidinyl)-1-azetidinyl]-4-pyrimidinyl}hydrazino)-3-oxopropyl]hydroxyformamide (65 mg, 64%). LCMS: (M+H)+: 478.1.

WORKUP

后处理

  1. customThe solvents were removed in vacuo
  2. customthe resulting crude product was purified by RP-HPLC