反应详情

Methyl (2R)-1-(N-{[(phenylmethyl)oxy]carbonyl}glycyl)-2-piperidinecarboxylate (2.029 g, 6.068 mmol) was dissolved in MeOH (30 mL), degassed and placed under argon. 10% Pd/C (610 mg) was added, and the contents were thoroughly degassed and placed under a hydrogen balloon for 3 h. The contents were then degassed, and the Pd/C was removed by filtration through Celite, washing with MeOH. The filtrate was concentrated in vacuo to provide pure (9aR)-tetrahydro-2H-pyrido[1,2-a]pyrazine-1,4(3H,6H)-dione (779 mg, 76%). LCMS: (M+H)+: 169.1.

1. customdegassed
2. addition10% Pd/C (610 mg) was added
3. customthe contents were thoroughly degassed
4. customfor 3 h
5. customThe contents were then degassed
6. customthe Pd/C was removed by filtration through Celite
7. washwashing with MeOH
8. concentrationThe filtrate was concentrated in vacuo