反应详情

Phenylmethyl (9aR)-octahydro-2H-pyrido[1,2-a]pyrazine-2-carboxylate (688 mg, 2.50 mmol) was dissolved in MeOH (15 mL), degassed and placed under argon. 10% Pd/C (206 mg) was added, and the contents were thoroughly degassed and placed under a hydrogen balloon for 2 h. The contents were then degassed, and the Pd/C was removed by filtration through Celite, washing with MeOH. The filtrate was concentrated in vacuo to provide pure (9aR)-octahydro-2H-pyrido[1,2-a]pyrazine (364 mg, 99%). LCMS: (M+H)+: 141.1.

1. customdegassed
2. addition10% Pd/C (206 mg) was added
3. customthe contents were thoroughly degassed
4. customfor 2 h
5. customThe contents were then degassed
6. customthe Pd/C was removed by filtration through Celite
7. washwashing with MeOH
8. concentrationThe filtrate was concentrated in vacuo