Triethylamine → HCID 86636998, compound

Participants

Reaction Steps

4,6-Dichloro-5-fluoro-2-methylpyrimidine (280 mg, 1.54 mmol) was dissolved in 5 mL of THF and stirred at room temperature. Methyl[2-(4-pyridinyl)ethyl]amine (210 mg, 1.54 mmol) was added, followed by triethylamine (240 μL, 1.69 mmol). The resulting reaction mixture was stirred overnight. The reaction was diluted with EtOAc, washed with brine, was dried (sodium sulfate) and was evaporated to provide 6-chloro-5-fluoro-N,2-dimethyl-N-[2-(4-pyridinyl)ethyl]-4-pyrimidinamine (350 mg, 81%) that was used without further purification. LCMS: (M+H)+: 281.1.

Provenance & Evidence