Hydrazine hydrate (1:1) → HCID 66936254, compound

Participants

Reaction Steps

6-Chloro-5-fluoro-N,2-dimethyl-N-[2-(4-pyridinyl)ethyl]-4-pyrimidinamine (350 mg, 1.25 mmol) was dissolved in 4 ml of DMSO and 4 ml of hydrazine monohydrate was added. The mixture was stirred overnight and was purified by RP-HPLC to provide 5-fluoro-6-hydrazino-N,2-dimethyl-N-[2-(4-pyridinyl)ethyl]-4-pyrimidinamine (220 mg, 63%). LCMS: (M+H)+: 277.2.

Provenance & Evidence