1,2-Dichloroethane → HCID 86636999, compound

Participants

Reaction Steps

A mixture of (2R)-3-cyclopentyl-2-({formyl[(phenylmethyl)oxy]amino}methyl)propanoic acid (230 mg, 0.76 mmol), 5-fluoro-6-hydrazino-N,2-dimethyl-N-[2-(4-pyridinyl)ethyl]-4-pyrimidinamine (210 mg, 0.76 mmol), EDC (180 mg, 0.91 mmol), HOAt (120 mg, 0.91 mmol), and NMM (0.25 mL, 2.28 mmol) in 5 ml DMF was stirred at room temperature overnight. The reaction mixture was then purified via reverse phase HPLC to provide {(2R)-2-(cyclopentylmethyl)-3-[2-(5-fluoro-2-methyl-6-{methyl[2-(4-pyridinyl)ethyl]amino}-4-pyrimidinyl)hydrazino]-3-oxopropyl}[(phenylmethyl)oxy]formamide (290 mg, 67%). LCMS: (M+H)+: 564.3.

Provenance & Evidence