HCID 86636999, compound → HCID 58000589, compound

Participants

Reaction Steps

{(2R)-2-(Cyclopentylmethyl)-3-[2-(5-fluoro-2-methyl-6-{methyl[2-(4-pyridinyl)ethyl]amino}-4-pyrimidinyl)hydrazino]-3-oxopropyl}[(phenylmethyl)oxy]formamide (290 mg, 0.51 mmol) was dissolved in 10 mL of MeOH. 10% Pd/carbon (60 mg) was added, and the contents were stirred under a hydrogen balloon for approximately 5 h. The contents were then filtered to remove the catalyst, and the filtrate was concentrated in vacuo to provide {(2R)-2-(cyclopentylmethyl)-3-[2-(5-fluoro-2-methyl-6-{methyl[2-(4-pyridinyl)ethyl]amino}-4-pyrimidinyl)hydrazino]-3-oxopropyl}hydroxyformamide (230 mg, 96%). LCMS: (M+H)+: 474.3.

Provenance & Evidence