Hydrochloric Acid → 2-chloro-5-fluoro-6-hydrazino-N-methyl-N-(1,3-thiazol-2-ylmethyl)-4-pyrimidinamine

Participants

Reaction Steps

Tris(1,1-dimethylethyl)2-{2-chloro-5-fluoro-6-[methyl (1,3-thiazol-2-ylmethyl)amino]-4-pyrimidinyl}-1,1,2-hydrazinetricarboxylate (1.51 g, 2.57 mmol) was dissolved in MeOH (25 mL) and HCl (4M in 1,4-dioxane) (25 mL) at room temperature. The reaction mixture was left to stir over 4 days and then evaporated to provide 2-chloro-5-fluoro-6-hydrazino-N-methyl-N-(1,3-thiazol-2-ylmethyl)-4-pyrimidinamine, assumed dihydrochloride, as a beige solid (0.9034 g, 98%). LCMS: (M+H−2HCl)+=289.0.

Provenance & Evidence