Hydrochloric Acid → HCID 66936209, compound

Participants

Reaction Steps

To a solution of the first eluting enantiomer of N,N,5,5-tetramethyl-1-(phenylmethyl)-3-pyrrolidinamine (1.0607 g, 4.569 mmol) in MeOH (40 mL) was added 1 N aq. HCl (9.1 mL, 9.1 mmol) and 10% Pd/C (50% water, 265 mg). The mixture was hydrogenated overnight and was then filtered through a 0.2 μm PTFE membrane. The solution was concentrated in vacuo, and the residue was azeotroped with MeOH (5×50 mL) to give crude N,N,5,5-tetramethyl-3-pyrrolidinamine dihydrochloride (1.0206 g, >100% crude yield) as a white foam. LCMS: (M+H)+: 143.1.

Provenance & Evidence