HCID 86637008, compound → HCID 58000582, compound

Participants

Reaction Steps

To a solution of [(2R)-3-(2-{2-chloro-6-[4-(dimethylamino)-2,2-dimethyl-1-pyrrolidinyl]-5-fluoro-4-pyrimidinyl}hydrazino)-2-(cyclopentylmethyl)-3-oxopropyl][(phenylmethyl)oxy]formamide (1.6493 g, 2.795 mmol) in MeOH (28 mL) was added 20% Pd(OH)2/C (50% water, 165 mg). The mixture was hydrogenated for 3.5 h, and then filtered. The solution was concentrated in vacuo, and the residue was purified by Gilson RPLC to provide [(2R)-3-(2-{2-chloro-6-[4-(dimethylamino)-2,2-dimethyl-1-pyrrolidinyl]-5-fluoro-4-pyrimidinyl}hydrazino)-2-(cyclopentylmethyl)-3-oxopropyl]hydroxyformamide (0.7580 g, 54%, single unknown diastereomer) as a pink solid following crystallization from EtOAc-hexanes. LCMS: (M+H)+: 500.3.

Provenance & Evidence