HCID 66936105, compound → HCID 66936080, compound

Participants

Reaction Steps

Phenylmethyl (2R,3R)-2,3,4-trimethyl-1-piperazinecarboxylate (328 mg, 1.25 mmol) was dissolved in 20 mL of MeOH, degassed and placed under argon. 10% Pd/C (81 mg) was added, and the contents were thoroughly degassed and placed under a hydrogen balloon for approximately 3 hrs. The contents were then degassed and filtered through Celite, and the Celite pad was washed with DCM and MeOH. After 2.75 mL 1N HCl was added, the resulting filtrate was concentrated in vacuo to provide the hydrochloride salt of (2R,3R)-1,2,3-trimethylpiperazine (251 mg, 100%). LCMS: (M+H)+: 129.1.

Provenance & Evidence