HCID 66936497, compound → HCID 66936145, compound

Participants

Reaction Steps

Phenylmethyl (2S,3S)-2,3,4-trimethyl-1-piperazinecarboxylate (323 mg, 1.23 mmol) (Example 198) was dissolved in 20 mL of MeOH, degassed and placed under argon. 10% Pd/C (81 mg) was added, and the contents were thoroughly degassed and placed under a hydrogen balloon for approximately 3 hrs. The contents were then degassed and filtered through Celite, and the Celite pad was washed with DCM and MeOH. After 2.70 mL 1N HCl was added, the resulting filtrate was concentrated in vacuo to provide the hydrochloride salt of (2S,3S)-1,2,3-trimethylpiperazine (246 mg, 100%). LCMS: (M+H)+: 129.1.

Provenance & Evidence