HCID 86637010, compound → HCID 58000731, compound

Participants

Reaction Steps

[(2R)-3-(2-{2-Chloro-5-fluoro-6-[(3-thienylmethyl)amino]-4-pyrimidinyl}hydrazino)-2-(cyclopentylmethyl)-3-oxopropyl](tetrahydro-2H-pyran-2-yloxy)formamide (0.7045 g, 1.272 mmol) was dissolved in acetic acid (8 mL) and water (2 mL). The reaction mixture was stirred overnight. The volatiles were evaporated, and the resulting residue was purified by RP-HPLC to provide [(2R)-3-(2-{2-chloro-5-fluoro-6-[(3-thienylmethyl)amino]-4-pyrimidinyl}hydrazino)-2-(cyclopentylmethyl)-3-oxopropyl]hydroxyformamide as a beige solid (0.2284 g, 38%). LCMS: (M+H)+=471.0.

Provenance & Evidence