Tris(1,1-dimethylethyl) 2-{2-chloro-5-fluoro-6-[(2-furanylmethyl)(methyl)amino]-4-pyrimidinyl}-1,1,2-hydrazinetricarboxylate → HCID 86637017, compound

Participants

Reaction Steps

Tris(1,1-dimethylethyl)2-{2-chloro-5-fluoro-6-[(2-furanylmethyl)(methyl)amino]-4-pyrimidinyl}-1,1,2-hydrazinetricarboxylate (7.1439 g, 12.51 mmol) was dissolved in MeOH (65 mL) and HCl (4M in 1,4-dioxane) (65 mL). The reaction mixture was left to stir 5 hours, evaporated and purified by RP-HPLC to provide 2-chloro-5-fluoro-N-(2-furanylmethyl)-6-hydrazino-N-methyl-4-pyrimidinamine as an orange solid (0.8561 g). LCMS: (M+H)+=272.1.

Provenance & Evidence