Dimethylamine → HCID 66936465, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-(diphenylmethyl)-3-ethyl-3-azetidinyl methanesulfonate (1.00 g, 2.89 mmol) (Ellsworth, Edmund Lee; Hoyer, Denton Wade; Hutchings, Kim Marie; Kendall, Jackie Diane; Murphy, Sean Timothy; Starr, Jeremy Tyson; Tran, Tuan Phong. WO 2005049605), dimethylamine (2 M in THF, 14.45 ml, 28.9 mmol) and TEA (0.80 ml, 5.78 mmol) in isopropanol was heated to 70° C. overnight. Standard work-up followed by RP-HPLC provided 1-(diphenylmethyl)-3-ethyl-N,N-dimethyl-3-azetidinamine (0.215 g, 25.3%). LCMS: (M+H)+ 295.2.

Provenance & Evidence