Diisopropylethylamine → [(2R)-2-(Cyclopentylmethyl)-3-(2-{5-fluoro-2-(fluoromethyl)-6-[(9aS)-hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-4-pyrimidinyl}hydrazino)-3-oxopropyl]hydroxyformamide

Participants

Reaction Steps

[(2R)-2-(Cyclopentylmethyl)-3-(2-{5-fluoro-2-(fluoromethyl)-6-[(9aS)-hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-4-pyrimidinyl}hydrazino)-3-oxopropyl]hydroxyformamide was prepared according to General Procedure A, utilizing (9aS)-octahydropyrazino[2,1-c][1,4]oxazine dihydrochloride (Example 22) in place of pyrrolidine, using 4,6-dichloro-5-fluoro-2-(fluoromethyl)pyrimidine in place of 4,6-dichloro-5-fluoro-2-methylpyrimidine, and using 3 equivalents of DIPEA in Part A. LCMS: (M+H)+: 498.3.

Provenance & Evidence