Triethylamine → HCID 86637019, compound

Participants

Reaction Steps

Tris(1,1-dimethylethyl)2-(2,6-dichloro-5-fluoro-4-pyrimidinyl)-1,1,2-hydrazinetricarboxylate (1.84 g, 3.71 mmol) was dissolved in THF (5 mL). To this solution was added triethylamine (0.62 mL, 4.4482 mmol), followed by [2-(3-thienyl)ethyl]amine (0.470 g, 3.70 mmol) which was semi-suspended in THF (15 mL). The reaction was left to stir overnight, then diluted with water and saturated NaCl. The aqueous layer was extracted with ethyl acetate. The organics were dried (MgSO4) and concentrated to produce tris(1,1-dimethylethyl)2-(2-chloro-5-fluoro-6-{[2-(3-thienyl)ethyl]amino}-4-pyrimidinyl)-1,1,2-hydrazinetricarboxylate as an orange oil (2.389 g). LCMS: (M+H)+=588.3.

Provenance & Evidence