Hydrochloric Acid → HCID 178514353, compound

Participants

Reaction Steps

Tris(1,1-dimethylethyl)2-(2-chloro-5-fluoro-6-{[2-(3-thienyl)ethyl]amino}-4-pyrimidinyl)-1,1,2-hydrazinetricarboxylate (2.389 g, 4.07 mmol) was dissolved in MeOH (25 mL) and HCl (4M in 1,4-dioxane) (25 mL) at room temperature. The reaction mixture was left to stir over 3 days, evaporated and purified by RP-HPLC to provide 2-chloro-5-fluoro-6-{[2-(3-thienyl)ethyl]amino}-4(1H)-pyrimidinone hydrazone as a brown sticky solid (0.1401 g). LCMS: (M+H)+=288.0.

Provenance & Evidence