HCID 66936064, compound → HCID 66936269, compound

Participants

Reaction Steps

(2S,5S)-1,2,5-Trimethyl-4-(phenylmethyl)piperazine (782 mg, 3.58 mmol) was dissolved in 50 mL of MeOH, degassed and placed under argon. 10% Pd/C (200 mg) was added, and the contents were thoroughly degassed and placed under a hydrogen balloon for approximately 3 hrs. The contents were then degassed and filtered through Celite, and the Celite pad was washed with DCM and MeOH. After 7.5 mL 1N HCl was added, the resulting filtrate was concentrated in vacuo to provide the hydrochloride salt of (2S,5S)-1,2,5-trimethylpiperazine (715 mg, 100%). LCMS: (M+H)+: 129.1.

Provenance & Evidence