Hydrochloric Acid → N,N-dimethyl-1-[(2S)-2-piperidinyl]methanamine hydrochloride

Participants

Reaction Steps

N,N-Dimethyl-1-[(2S)-1-(phenylmethyl)-2-piperidinyl]methanamine (590 mg, 2.539 mmol) was dissolved in a mixture of MeOH (20 mL) and 1N HCl (5.5 mL, 5.5 mmol), degassed and placed under argon. 10% Pd/C (117 mg) was added, and the contents were thoroughly degassed and placed under a hydrogen balloon for 2 h. The contents were then degassed, and the Pd/C was removed by filtration through a fiberglass filter, washing with MeOH. The filtrate was concentrated in vacuo to provide pure N,N-dimethyl-1-[(2S)-2-piperidinyl]methanamine hydrochloride (425 mg, 78%). LCMS: (M+H)+: not detected.

Provenance & Evidence