Hydrochloric Acid → 2-chloro-5-fluoro-6-hydrazino-N-(4-methyl-1-piperazinyl)-N-(1,3-thiazol-2-ylmethyl)-4-pyrimidinamine

Participants

Reaction Steps

Tris(1,1-dimethylethyl)2-{2-chloro-5-fluoro-6-[(4-methyl-1-piperazinyl)(1,3-thiazol-2-ylmethyl)amino]-4-pyrimidinyl}-1,1,2-hydrazinetricarboxylate (0.2014 g, 0.299 mmol) was dissolved in DCM (20 mL) under a nitrogen atmosphere. Then 2M HCl (2.99 mL, 5.98 mmol) was added, and the reaction was stirred overnight. The reaction mixture was evaporated to provide crude 2-chloro-5-fluoro-6-hydrazino-N-(4-methyl-1-piperazinyl)-N-(1,3-thiazol-2-ylmethyl)-4-pyrimidinamine as a yellow solid (0.1683 g). LCMS: (M+H)+=373.0.

Provenance & Evidence