HCID 178454061, compound → HCID 178508358, compound

Participants

Reaction Steps

A mixture of cis-[4-(1-aminoisoquinolin-6-yloxy)cyclohexyl]carbamic acid tert-butyl ester (14 mg) in dichloromethane (900 μl) and trifluoroacetic acid (100 μl) was stirred at ambient temperature for 3 h. The mixture was concentrated in vacuo then purified by prep-HPLC to give gave cis-6-(4-aminocyclohexyloxy)isoquinolin-1-ylamine (8.1 mg), EI-MS: m/z=258.5 [M+H]+. 1H NMR (methanol D4) δ1.55-1.80 (6H, m), 2.05-2.15 (2H, m), 2.75-2.85 (1H, m), 4.65-4.75 (1H, obscured broad s), 6.88 (1H, d), 7.08-7.15 (2H, m), 7.64 (1H, d), 7.99 (1H, d).

Provenance & Evidence