反应详情

Toluene (750 ml) and thionyl chloride (11 ml) were subsequently added to 3-(3-methoxy-4-methylphenyl)acrylic acid (20 g, 0.104 mol) at room temperature. The suspension was refluxed for 2 h while vigorously stirring to give a clear slightly yellow solution. The reaction mixture was concentrated in vacuo, then toluene added and the mixture re-concentrated in vacuo to give 3-(3-methoxy-4-methylphenyl)acryloyl chloride for use in the next step.

1. temperatureThe suspension was refluxed for 2 h
2. customto give a clear slightly yellow solution
3. concentrationThe reaction mixture was concentrated in vacuo
4. additiontoluene added
5. concentrationthe mixture re-concentrated in vacuo