3-Methoxybenzaldehyde → 1-Chloro-6-methoxyisoquinoline

HRID 1366756노트

반응식

HRID 1366756 반응식
COC1C=C(C=CC=1)C=O.[Cl:11][C:12]1[C:21]2[C:16](=[CH:17][C:18]([O:23][CH3:24])=[C:19](C)[CH:20]=2)[CH:15]=[CH:14][N:13]=1>>[Cl:11][C:12]1[C:21]2[C:16](=[CH:17][C:18]([O:23][CH3:24])=[CH:19][CH:20]=2)[CH:15]=[CH:14][N:13]=1.[Cl:11][C:12]1[C:21]2[C:16](=[CH:17][C:18]([OH:23])=[CH:19][CH:20]=2)[CH:15]=[CH:14][N:13]=1

참가 물질

4

반응물 2

HCID 115693-MethoxybenzaldehydeHCID 537828801-Chloro-6-methoxy-7-methylisoquinoline

생성물 2

HCID 219010741-Chloro-6-methoxyisoquinolineHCID 1357421771-chloro-2H-isoquinolin-6-one

실험 절차

The 1-chloro-6-methoxyisoquinoline was prepared according to Example 1A or from 3-methoxybenzaldehyde using the same procedure as in Example 5A. The 1-chloro-6-methoxy-7-methylisoquinoline was then demethylated according Example 1E to afford 1-chloro isoquinolin-6-ol.

출처 및 근거

ORD 기록
ord-6f9279d4a5e546538692004d2274eff7
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07893088B2

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