反应详情

Prepared from 2-amino-5-bromo-4-methylpyridine and 4-(N -piperidinylsulfonyl)thiophenol according to General Method 11 step 1 followed by reaction with 2,4-dichlorophenylsulfonyl chloride according to General Method 11 step 2. 1H NMR (CDCl3): 13.00 (1 H, br s, NH), 8.38 (1 H, s, A-ring CH ortho to 2×Cl), 8.13 (1 H, d, J 11 Hz, A-ring CH ortho to SO2NH), 7.53 & 7.05 (2×2 H, 2×d, 2×J 10 Hz, Ar CH's of C-ring), 7.43 & 7.14 (2×1 H, 2×s, pyridyl CH's), 7.34 (1 H, d, J 11 Hz, A-ring CH ortho to Cl), 2.90-2.81 (4H, m, CH2NCH2), 2.21 (3H, s, CH3), 1.62-1.48 (4 H, m, CH2CH2CH2CH2CH2), 1.39-1.27 (2 H, m, CH2CH2CH2CH2CH2). Hplc (Luna 2, Gradient 5): rt=6.43 minutes. LC/MS rt=7.43 minutes, 572/574 (MH+).

1. customrt=6.43 minutes
2. customLC/MS rt=7.43 minutes, 572/574 (MH+)